| Pair Name | Isodeoxyelephantopin, Cisplatin | ||
| Phytochemical Name | Isodeoxyelephantopin (PubChem CID: 38359583 ) | ||
| Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Isodeoxyelephantopin, Cisplatin | |||
| Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->ROS generation | |||
| Gene Regulation | Up-regulation | Activity | MAPK8 | hsa5599 |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| Down-regulation | Activity | TXNRD1 | hsa7296 | |
| In Vitro Model | HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 |
| RKO | Colon carcinoma | Homo sapiens (Human) | CVCL_0504 | |
| In Vivo Model | HCT116 cells (5×10⁶ cells in 100 μl of phosphate-buffered saline) were injected subcutaneously into the right back of nude mice. | |||
| Result | Our study provide a preclinical proof-of-concept for ESI as a potential strategy for colon cancer treatment. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Isodeoxyelephantopin Inactivates Thioredoxin Reductase 1 and Activates ROS-Mediated JNK Signaling Pathway to Exacerbate Cisplatin Effectiveness in Human Colon Cancer Cells. Front Cell Dev Biol. 2020 Sep 22;8:580517. doi: 10.3389/fcell.2020.580517. | Click |
