| Pair Name | Honokiol, Metformin | ||
| Phytochemical Name | Honokiol (PubChem CID: 72303 ) | ||
| Anticancer drug Name | Metformin (PubChem CID: 4091 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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MOL
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| Pair Name | Honokiol, Metformin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Down-regulation | Phosphorylation | RPS6KB1 | hsa6198 | |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 | |
| SK-BR-3 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0033 | |
| Result | The combination of honokiol with metformin is considered an effective approach to induce death in hormone-resistant cells. Honokiol is of interest as a natural compound with antiproliferative activity against breast cancers, including resistant tumors. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Honokiol inhibits the growth of hormone-resistant breast cancer cells: its promising effect in combination with metformin. Res Pharm Sci. 2023 Aug 20;18(5):580-591. doi: 10.4103/1735-5362.383712. | Click |
