| Pair Name | Homoharringtonine, Cisplatin | ||
| Phytochemical Name | Homoharringtonine (PubChem CID: 285033 ) | ||
| Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
| Structure of Phytochemical |
|
Download
2D
MOL
3D
MOL
|
|
| Structure of Anticancer Drug |
|
Download
2D
MOL
3D
MOL
|
|
| Pair Name | Homoharringtonine, Cisplatin | |||
| Disease Info | [ICD-11: 2C73] | Ovarian cancer | Investigative | |
| Biological Phenomena | Induction-->DNA damage | |||
| Gene Regulation | Down-regulation | Expression | CDKN2A | hsa1029 |
| Down-regulation | Expression | TP53 | hsa7157 | |
| In Vitro Model | OVCAR-3 | High grade ovarian serous adenocarcinoma | Homo sapiens (Human) | CVCL_0465 |
| A2780/CP70 | Ovarian endometrioid adenocarcinoma | Homo sapiens (Human) | CVCL_0135 | |
| Result | Combinatorial treatment of ovarian cancer cells with harringtonine and cisplatin results in increased cisplatin-DNA adducts | |||
| No. | Title | Href |
|---|---|---|
| 1 | Combinatorial treatment of ovarian cancer cells with harringtonine and cisplatin results in increased cisplatin-DNA adducts. Oncol Rep. 2004 Apr;11(4):833-8. | Click |
