4',5,7-trihydroxy-6-methoxy-flavone, 4',5,7-trihydroxy-6-methoxyflavone, dinatin, hispidulin
| Name | Hispidulin | ||
| PubChem CID | 5281628 | ||
| Molecular Weight | 300.26g/mol | ||
| Synonyms |
4',5,7-trihydroxy-6-methoxy-flavone, 4',5,7-trihydroxy-6-methoxyflavone, dinatin, hispidulin |
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| Formula | C₁₆H₁₂O₆ | ||
| SMILES | COC1=C(C2=C(C=C1O)OC(=CC2=O)C3=CC=C(C=C3)O)O | ||
| InChI | 1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3 | ||
| InChIKey | IHFBPDAQLQOCBX-UHFFFAOYSA-N | ||
| CAS Number | 1447-88-7 | ||
| ChEMBL ID | CHEMBL293776 | ||
| ChEBI ID | CHEBI:75902 | ||
| Herb ID | HBIN029430 | ||
| Drug Bank ID | DB14008 | ||
| KEGG ID | C10058 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | TianYeJu | ||
| Use Part | Leaf | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asterales
-->Family: Asteraceae
-->Genus: Stevia
-->Species: Stevia rebaudiana
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| Pair Name | Hispidulin, Temozolomide | |||
| Partner Name | Temozolomide | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Inhibition-->Autophagy | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Expression | MAP1LC3A | hsa84557 | |
| Up-regulation | Expression | MAP1LC3B | hsa81631 | |
| In Vitro Model | U-87MG ATCC | Glioblastoma | Homo sapiens (Human) | CVCL_0022 |
| Result | These results collectively suggested that the combination of hispidulin and TMZ could improve the antitumor efficiency of TMZ against malignant gliomas. | |||
