| Pair Name | Hexahydrocurcumin, Fluorouracil | ||
| Phytochemical Name | Hexahydrocurcumin (PubChem CID: 5318039 ) | ||
| Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Hexahydrocurcumin, Fluorouracil | |||
| Disease Info | [ICD-11: 2B90.Z] | Colon cancer | Investigative | |
| Gene Regulation | Down-regulation | Expression | PTGS2 | hsa5743 |
| In Vitro Model | HT-29 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0320 |
| Result | HHC together with 5-FU exerts a synergistic effect and may prove chemotherapeutically useful in treating human colon cancer. | |||
| Pair Name | Hexahydrocurcumin, Fluorouracil | |||
| Disease Info | [ICD-11: 2B90.Z] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | PTGS2 | hsa5743 |
| In Vivo Model | Male Wistar rats weighing 100-120 g were used in study. | |||
| Result | The combined effects of HHC with 5-FU exhibit a synergistic inhibition by decreasing ACF formation mediated by down-regulation of COX-2 expression. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Hexahydrocurcumin enhances inhibitory effect of 5-fluorouracil on HT-29 human colon cancer cells. World J Gastroenterol. 2012 May 21;18(19):2383-9. doi: 10.3748/wjg.v18.i19.2383. | Click |
| 2 | Effects of hexahydrocurcumin in combination with 5-fluorouracil on dimethylhydrazine-induced colon cancer in rats. World J Gastroenterol. 2012 Dec 21;18(47):6951-9. doi: 10.3748/wjg.v18.i47.6951. | Click |
