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Phytochemical Details

01. General Information

Name	Hexahydrocurcumin
PubChem CID	5318039
Molecular Weight	374.4g/mol
Synonyms	hexahydrocurcumin
Formula	C₂₁H₂₆O₆
SMILES	COC1=C(C=CC(=C1)CCC(CC(=O)CCC2=CC(=C(C=C2)O)OC)O)O
InChI	1S/C21H26O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h5-6,9-12,16,22,24-25H,3-4,7-8,13H2,1-2H3
InChIKey	RSAHICAPUYTWHW-UHFFFAOYSA-N
CAS Number	36062-05-2
ChEMBL ID	CHEMBL479650
ChEBI ID	CHEBI:81358
Herb ID	HBIN029301
KEGG ID	C17826
Structure		Download 2D MOL 3D MOL

02. Source Information of Phytochemical

(1) Zingiber officinale Hot

Chineses Pinyin	GanJiang
Use Part	Rhizome
Habitat	China
Flavor	Pungent
Meridian Tropism	Spleen, Stomach, Kidney, Heart, Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Zingiberales 　　　　-->Family: Zingiberaceae 　　　　　-->Genus: Zingiber 　　　　　　-->Species: Zingiber officinale

(2) Curcuma longa Warm

Chineses Pinyin	JiangHuang
Use Part	Tuberoid
Habitat	SiChuan, FuJian, GuangDong, ZheJiang, JiangXi
Flavor	Pungent, Bitter
Meridian Tropism	Spleen, Liver
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Zingiberales 　　　　-->Family: Zingiberaceae 　　　　　-->Genus: Curcuma 　　　　　　-->Species: Curcuma longa

(3) Curcuma wenyujin Warm

Chineses Pinyin	PianJiangHuang
Use Part	Rhizome
Habitat	JiangSu, ZheJiang, FuJian, GuangDong, GuangXi, SiChuan, YunNan
Flavor	Pungent, Bitter
Meridian Tropism	Spleen, Liver
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Zingiberales 　　　　-->Family: Zingiberaceae 　　　　　-->Genus: Curcuma 　　　　　　-->Species: Curcuma wenyujin

(4) Zingiber officinale Warm

Chineses Pinyin	ShengJiang
Use Part	Rhizome, Cork, Leaf
Habitat	SiChuan, GuiZhou, HuBei, GuangDong, GuangXi
Flavor	Pungent
Meridian Tropism	Lung, Spleen, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Zingiberales 　　　　-->Family: Zingiberaceae 　　　　　-->Genus: Zingiber 　　　　　　-->Species: Zingiber officinale

(5) Alpinia officinarum Hot

Chineses Pinyin	GaoLiangJiang
Use Part	Rhizome
Habitat	HaiNan, GuangXi, YunNan, TaiWan, GuangDong
Flavor	Pungent
Meridian Tropism	Spleen, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Zingiberales 　　　　-->Family: Zingiberaceae 　　　　　-->Genus: Alpinia 　　　　　　-->Species: Alpinia officinarum

03. Combinatorial Therapeutic Effect(s)

Synergistic Effect

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Drug(s) whose efficacy can be enhanced by this phytochemical

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Combination Pair ID: 501

Ref_1

Pair Name	Hexahydrocurcumin, Fluorouracil
Partner Name	Fluorouracil
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	PTGS2	hsa5743
In Vivo Model	Male Wistar rats weighing 100-120 g were used in study.
Result	The combined effects of HHC with 5-FU exhibit a synergistic inhibition by decreasing ACF formation mediated by down-regulation of COX-2 expression.

Combination Pair ID: 502

Ref_2

Pair Name	Hexahydrocurcumin, Fluorouracil
Partner Name	Fluorouracil
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Gene Regulation	Down-regulation	Expression	PTGS2	hsa5743
In Vitro Model	HT-29	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0320
Result	HHC together with 5-FU exerts a synergistic effect and may prove chemotherapeutically useful in treating human colon cancer.

04. Reference

No.	Title	Href
1	Effects of hexahydrocurcumin in combination with 5-fluorouracil on dimethylhydrazine-induced colon cancer in rats. World J Gastroenterol. 2012 Dec 21;18(47):6951-9. doi: 10.3748/wjg.v18.i47.6951.	`Click`
2	Hexahydrocurcumin enhances inhibitory effect of 5-fluorouracil on HT-29 human colon cancer cells. World J Gastroenterol. 2012 May 21;18(19):2383-9. doi: 10.3748/wjg.v18.i19.2383.	`Click`