geraniol, geraniol, (E)-isomer, geraniol, (Z)-isomer, geraniol, 1-(14)C-labeled, (E)-isomer, geraniol, 2-(14)C-labeled, (E)-isomer, geraniol, titanium (4+) salt, nerol
| Name | Geraniol | ||
| PubChem CID | 637566 | ||
| Molecular Weight | 154.25g/mol | ||
| Synonyms |
geraniol, geraniol, (E)-isomer, geraniol, (Z)-isomer, geraniol, 1-(14)C-labeled, (E)-isomer, geraniol, 2-(14)C-labeled, (E)-isomer, geraniol, titanium (4+) salt, nerol |
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| Formula | C₁₀H₁₈O | ||
| SMILES | CC(=CCCC(=CCO)C)C | ||
| InChI | 1S/C10H18O/c1-9(2)5-4-6-10(3)7-8-11/h5,7,11H,4,6,8H2,1-3H3/b10-7+ | ||
| InChIKey | GLZPCOQZEFWAFX-JXMROGBWSA-N | ||
| CAS Number | 624-15-7 | ||
| ChEMBL ID | CHEMBL25719 | ||
| ChEBI ID | CHEBI:17447 | ||
| Herb ID | HBIN027528 | ||
| Drug Bank ID | DB10829 | ||
| KEGG ID | C01500 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | MeiGui | ||
| Use Part | Bud | ||
| Habitat | BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, Shaanxi, GanSu, QingHai, NingXia, XinJiang, SiChuan, GuiZhou, YunNan, XiZang, ChongQing, Japan , North Korea | ||
| Flavor | Sweet; Slightly Bitter | ||
| Meridian Tropism | Liver; Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Rosales
-->Family: Rosaceae
-->Genus: Rosa
-->Species: Rosa rugosa
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| Pair Name | Geraniol, Simvastatin | |||
| Partner Name | Simvastatin | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Inhibition-->Cell proliferation | |||
| In Vitro Model | Hep-G2 | Hepatoblastoma | Homo sapiens (Human) | CVCL_0027 |
| Result | Our results demonstrate that the combination of simvastatin and geraniol synergistically inhibited cholesterol biosynthesis and proliferation of Hep G2 cell line, contributing to a better understanding of the action of a component of essential oils targeting a complex metabolic pathway, which would improve the use of drugs or their combination in the fight against cancer and/or cardiovascular diseases. | |||
| Pair Name | Geraniol, Fluorouracil | |||
| Partner Name | Fluorouracil | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Gene Regulation | Down-regulation | Expression | MTOR | hsa2475 |
| Up-regulation | Expression | PTEN | hsa5728 | |
| Down-regulation | Expression | TYMS | hsa7298 | |
| In Vivo Model | The aim of the current work is to investigate the potential therapeutic as well as chemosensitizing effects of geraniol on breast carcinoma induced in mice through examination of tumour biomarkers and histopathology profile. | |||
| Result | It can be concluded that geraniol could represent a promising avenue for breast cancer treatment as well as a potential sensitizing agent when combined with chemotherapeutic drugs. | |||
| Pair Name | Geraniol, Fluorouracil | |||
| Partner Name | Fluorouracil | |||
| Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->DNA synthesis | |||
| In Vitro Model | Caco-2 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0025 |
| SW620 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0547 | |
| In Vivo Model | Colorectal tumor TC118 obtained from patients was grafted by subcutaneous implantation of 15 mm3 tumor fragments into the scapular area of nude mice. | |||
| Result | Geraniol modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts | |||
| Pair Name | Geraniol, Gemcitabine | |||
| Partner Name | Gemcitabine | |||
| Disease Info | [ICD-11: 2C10.0] | Pancreatic ductal adenocarcinoma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| In Vitro Model | BxPC-3 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_0186 |
| Result | Geraniol inhibited the proliferation of BXPC-3 cells. Geraniol significantly increased the antiproliferative and apoptosis-inducing effects of gemcitabine on BXPC-3 cells. Maximum inhibition of BXPC-3 cells was achieved with geraniol treatment for 24 h before gemcitabine treatment. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Geraniol and simvastatin show a synergistic effect on a human hepatocarcinoma cell line. Cell Biochem Funct. 2011 Aug;29(6):452-8. doi: 10.1002/cbf.1772. | Click |
| 2 | Geraniol suppresses tumour growth and enhances chemosensitivity of 5-fluorouracil on breast carcinoma in mice: involvement of miR-21/PTEN signalling. J Pharm Pharmacol. 2023 Aug 1;75(8):1130-1139. doi: 10.1093/jpp/rgad060. | Click |
| 3 | Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts. Cancer Lett. 2004 Nov 8;215(1):53-9. doi: 10.1016/j.canlet.2004.06.019. | Click |
| 4 | Inhibitory effect of geraniol in combination with gemcitabine on proliferation of BXPC-3 human pancreatic cancer cells. J Int Med Res. 2013 Aug;41(4):993-1001. doi: 10.1177/0300060513480919. | Click |
