| Pair Name | Flavokawain B, Bortezomib | ||
| Phytochemical Name | Flavokawain B (PubChem CID: 5356121 ) | ||
| Anticancer drug Name | Bortezomib (PubChem CID: 387447 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Flavokawain B, Bortezomib | |||
| Disease Info | [ICD-11: 2C82] | Prostate cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | CDKN1A | hsa1026 |
| Up-regulation | cleavage | PARP1 | hsa142 | |
| Up-regulation | Expression | PSMD9 | hsa5715 | |
| Down-regulation | Expression | SKP2 | hsa6502 | |
| In Vitro Model | LNCaP | Prostate carcinoma | Homo sapiens (Human) | CVCL_0395 |
| PC-3 | Prostate carcinoma | Homo sapiens (Human) | CVCL_0035 | |
| LNCaP C4-2B | Prostate carcinoma | Homo sapiens (Human) | CVCL_4784 | |
| Result | These findings provide a rationale for further investigating combination of FKB and Bortezomib for treatment of RB deficient, castration-resistant prostate cancer. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation. Cell Commun Signal. 2019 Mar 18;17(1):25. doi: 10.1186/s12964-019-0338-2. | Click |
