3beta-friedelinol, epi-friedelinol, epifriedelanol, friedelanol, friedelinol, friedelinol, (3beta)-isomer
| Name | Epifriedelanol | ||
| PubChem CID | 119242 | ||
| Molecular Weight | 428.7g/mol | ||
| Synonyms |
3beta-friedelinol, epi-friedelinol, epifriedelanol, friedelanol, friedelinol, friedelinol, (3beta)-isomer |
||
| Formula | C₃₀H₅₂O | ||
| SMILES | CC1C(CCC2C1(CCC3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C)C)C)C)C)C)O | ||
| InChI | 1S/C30H52O/c1-20-21(31)9-10-22-27(20,5)12-11-23-28(22,6)16-18-30(8)24-19-25(2,3)13-14-26(24,4)15-17-29(23,30)7/h20-24,31H,9-19H2,1-8H3/t20-,21-,22+,23-,24+,26+,27+,28-,29+,30-/m0/s1 | ||
| InChIKey | XCDQFROEGGNAER-PFOIMGGJSA-N | ||
| CAS Number | 16844-71-6 | ||
| ChEMBL ID | CHEMBL464649 | ||
| ChEBI ID | CHEBI:80941 | ||
| Herb ID | HBIN025338 | ||
| KEGG ID | C17123 | ||
| Structure | 
|
Download
2D
MOL
3D
MOL
|
|
| Chineses Pinyin | HuoXiang | ||
| Use Part | Aerial Parts | ||
| Habitat | GuangDong, HaiNan | ||
| Flavor | Pungent | ||
| Meridian Tropism | Spleen, Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Pogostemon
-->Species: Pogostemon cablin
|
||
| Chineses Pinyin | ShanYao | ||
| Use Part | Rhizome | ||
| Habitat | China | ||
| Flavor | Sweet | ||
| Meridian Tropism | Spleen, Lung, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Dioscoreales
-->Family: Dioscoreaceae
-->Genus: Dioscorea
-->Species: Dioscorea opposita
|
||
| Chineses Pinyin | CiTong | ||
| Use Part | Dried bark or root cortex | ||
| Flavor | Pungent; Bitter | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Erythrina
-->Species: Erythrina stricta
|
||
| Pair Name | Epifriedelanol, Doxorubicin | |||
| Partner Name | Doxorubicin | |||
| Disease Info | [ICD-11: 2B33.2] | Chronic myeloid leukemia | Investigative | |
| Gene Regulation | Up-regulation | Expression | NR1I2 | hsa8856 |
| Up-regulation | Expression | CXADR | hsa1525 | |
| Down-regulation | Expression | ABCB1 | hsa5243 | |
| Down-regulation | Expression | ABCC2 | hsa1244 | |
| In Vitro Model | K562/Adr | Blast phase chronic myelogenous leukemia | Homo sapiens (Human) | CVCL_3827 |
| Result | The present study demonstrated that Epi could enhance Adr-induced cytotoxicity towards K562/ADM cells accompanied by the down-regulation of P-gp and MRP2. | |||
