| Pair Name | Emodin, Doxorubicin | ||
| Phytochemical Name | Emodin (PubChem CID: 3220 ) | ||
| Anticancer drug Name | Doxorubicin (PubChem CID: 31703 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Emodin, Doxorubicin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->DNA damage | |||
| Gene Regulation | Down-regulation | Expression | AKT1 | hsa207 |
| Down-regulation | Expression | XRCC1 | hsa7515 | |
| Down-regulation | Expression | PARP1 | hsa142 | |
| Down-regulation | Expression | RAD51 | hsa5888 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| In Vitro Model | MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 |
| MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 | |
| Result | Emodin Interferes With AKT1-Mediated DNA Damage and Decreases Resistance of Breast Cancer Cells to Doxorubicin | |||
| No. | Title | Href |
|---|---|---|
| 1 | Emodin interferes with AKT1-mediated DNA damage and decreases resistance of breast cancer cells to doxorubicin. Front Oncol. 2023 Dec 7;13:1337635. doi: 10.3389/fonc.2023.1337635. | Click |
