| Pair Name | Dendrobine, Cisplatin | ||
| Phytochemical Name | Dendrobine (PubChem CID: 442523 ) | ||
| Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Dendrobine, Cisplatin | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Balance of Treg/Th17 cells | |||
| Gene Regulation | Down-regulation | Expression | FOXP3 | hsa50943 |
| Up-regulation | Expression | IL17A | hsa3605 | |
| In Vitro Model | NCI-H1299 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0060 |
| In Vivo Model | Dendrobine combined with cisplatin prolonged the survival of mice implanted with H1299 cells and reduced tumor volume compared with single drug application. | |||
| Result | Synergism Effect of Dendrobine on Cisplatin in Treatment of H1299 by Modulating the Balance of Treg/Th17 | |||
| No. | Title | Href |
|---|---|---|
| 1 | Synergism Effect of Dendrobine on Cisplatin in Treatment of H1299 by Modulating the Balance of Treg/Th17. Anticancer Agents Med Chem. 2023;23(1):105-112. doi: 10.2174/1871520622666220520093837. | Click |
