dendrobine, dendrobine hydrochloride
| Name | Dendrobine | ||
| PubChem CID | 442523 | ||
| Molecular Weight | 263.37g/mol | ||
| Synonyms |
dendrobine, dendrobine hydrochloride |
||
| Formula | C₁₆H₂₅NO₂ | ||
| SMILES | CC(C)C1C2C3CCC4C3(C(C1OC2=O)N(C4)C)C | ||
| InChI | 1S/C16H25NO2/c1-8(2)11-12-10-6-5-9-7-17(4)14(16(9,10)3)13(11)19-15(12)18/h8-14H,5-7H2,1-4H3/t9-,10+,11+,12-,13-,14-,16+/m1/s1 | ||
| InChIKey | RYAHJFGVOCZDEI-UFFNCVEVSA-N | ||
| CAS Number | 2115-91-5 | ||
| ChEMBL ID | CHEMBL4173720 | ||
| ChEBI ID | CHEBI:4400 | ||
| Herb ID | HBIN023277 | ||
| KEGG ID | C09943 | ||
| Structure | 
|
Download
2D
MOL
3D
MOL
|
|
| Chineses Pinyin | ShiHu | ||
| Use Part | Stem | ||
| Habitat | GuangXi, GuiZhou, YunNan, HuBei | ||
| Flavor | Sweet | ||
| Meridian Tropism | Stomach, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asparagales
-->Family: Orchidaceae
-->Genus: Dendrobium
-->Species: Dendrobium nobile
|
||
| Pair Name | Dendrobine, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Balance of Treg/Th17 cells | |||
| Gene Regulation | Down-regulation | Expression | FOXP3 | hsa50943 |
| Up-regulation | Expression | IL17A | hsa3605 | |
| In Vitro Model | NCI-H1299 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0060 |
| In Vivo Model | Dendrobine combined with cisplatin prolonged the survival of mice implanted with H1299 cells and reduced tumor volume compared with single drug application. | |||
| Result | Synergism Effect of Dendrobine on Cisplatin in Treatment of H1299 by Modulating the Balance of Treg/Th17 | |||
