| Pair Name | Bixin, Dacarbazine | ||
| Phytochemical Name | Bixin (PubChem CID: 5281226 ) | ||
| Anticancer drug Name | Dacarbazine (PubChem CID: 135398738 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Bixin, Dacarbazine | |||
| Disease Info | [ICD-11: 2C30] | Melanoma | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| Gene Regulation | Up-regulation | Activity | CASP3 | hsa836 |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| In Vitro Model | A2058 | Amelanotic melanoma | Homo sapiens (Human) | CVCL_1059 |
| Result | These data suggest that bixin exerts intrinsic antimelanoma activity by mechanisms complementary to those of dacarbazine, encouraging its use in combined therapy for cutaneous melanoma treatment. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Bixin, an apocarotenoid isolated from Bixa orellana L., sensitizes human melanoma cells to dacarbazine-induced apoptosis through ROS-mediated cytotoxicity. Food Chem Toxicol. 2019 Mar;125:549-561. doi: 10.1016/j.fct.2019.02.013. | Click |
