| Pair Name | Betulin, Gefitinib | ||
| Phytochemical Name | Betulin (PubChem CID: 72326 ) | ||
| Anticancer drug Name | Gefitinib (PubChem CID: 123631 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Betulin, Gefitinib | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Ferroptosis | |||
| Gene Regulation | Down-regulation | Expression | GSS | hsa2937 |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| In Vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 |
| NCI-H460 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0459 | |
| In Vivo Model | A xenograft model was constructed in vivo to investigate the role of the combination treatment of betulin and gefitinib in NSCLC tumor growth, it also inhibited the tumor growth of NSCLC in vivo. | |||
| Result | Co-treatment of betulin and gefitinib is effective against EGFR wild-type/KRAS-mutant non-small cell lung cancer by inducing ferroptosis | |||
| No. | Title | Href |
|---|---|---|
| 1 | Co-treatment of betulin and gefitinib is effective against EGFR wild-type/KRAS-mutant non-small cell lung cancer by inducing ferroptosis. Neoplasma. 2022 May;69(3):648-656. doi: 10.4149/neo_2022_211103N1568. | Click |
