| Pair Name | Beta-Caryophyllene, Doxorubicin | ||
| Phytochemical Name | Beta-Caryophyllene (PubChem CID: 5281515 ) | ||
| Anticancer drug Name | Doxorubicin (PubChem CID: 31703 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Beta-Caryophyllene, Doxorubicin | |||
| Disease Info | [ICD-11: 2C17] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| Gene Regulation | Down-regulation | Phosphorylation | STAT3 | hsa6774 |
| Down-regulation | Phosphorylation | H2AX | hsa3014 | |
| In Vitro Model | Mz-ChA-1 | Gallbladder carcinoma | Homo sapiens (Human) | CVCL_6932 |
| Result | This evidence highlighted a possible role of STAT3 as a final effector of a complex network regulated by β-caryophyllene, which leads to an enhanced doxorubicin-sensitivity of cholangiocarcinoma cells and a lowered chemotherapy toxicity in nonmalignant cholangiocytes, thus strengthening the interest for this natural sesquiterpene as a dual-acting chemosensitizing and chemopreventive agent. | |||
| No. | Title | Href |
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| 1 | Modulation of STAT3 Signaling, Cell Redox Defenses and Cell Cycle Checkpoints by β-Caryophyllene in Cholangiocarcinoma Cells: Possible Mechanisms Accounting for Doxorubicin Chemosensitization and Chemoprevention. Cells. 2020 Apr 2;9(4):858. doi: 10.3390/cells9040858. | Click |
