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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Berberine, Lapatinib
Phytochemical Name Berberine (PubChem CID: 2353 )
Anticancer drug Name Lapatinib (PubChem CID: 208908 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Reversing Drug Resistance
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Combination Pair ID: 887
Ref_1
Pair Name Berberine, Lapatinib
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Biological Phenomena Induction-->ROS generation
Gene Regulation Up-regulation Expression ROS1 hsa6098
Down-regulation Expression MYC hsa4609
Down-regulation Expression NFE2L2 hsa4780
In Vitro Model BT-474LabR Lapatinib-resistant breast adenocarcinoma Homo sapiens (Human) N.A.
AU-565LapR Lapatinib-resistant breast adenocarcinoma Homo sapiens (Human) N.A.
Result Berberine can upset the ROS balance by downregulating c-Myc to reverse the Lapatinib resistance. Our finding provides a novel strategy of using berberine to overcome Lapatinib resistance.
03. Reference
No. Title Href
1 Berberine reverses Lapatinib resistance of HER2-positive breast cancer cells by increasing the level of ROS. Cancer Biol Ther. 2016;17(9):925-934. doi:10.1080/15384047.2016.1210728 Click
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