| Pair Name | Berberine, Lapatinib | ||
| Phytochemical Name | Berberine (PubChem CID: 2353 ) | ||
| Anticancer drug Name | Lapatinib (PubChem CID: 208908 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Berberine, Lapatinib | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->ROS generation | |||
| Gene Regulation | Down-regulation | Expression | MYC | hsa4609 |
| Down-regulation | Expression | NFE2L2 | hsa4780 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| In Vitro Model | BT-474LabR | Lapatinib-resistant breast adenocarcinoma | Homo sapiens (Human) | N.A. |
| AU-565LapR | Lapatinib-resistant breast adenocarcinoma | Homo sapiens (Human) | N.A. | |
| Result | Berberine reverses Lapatinib resistance of HER2-positive breast cancer cells by increasing the level of ROS | |||
| No. | Title | Href |
|---|---|---|
| 1 | Berberine reverses Lapatinib resistance of HER2-positive breast cancer cells by increasing the level of ROS. Cancer Biol Ther. 2016;17(9):925-934. doi:10.1080/15384047.2016.1210728 | Click |
