InterPAD - DETAILS

17-hydro-9-dehydro-andrographolide, andrographolide, isoandrographolide

No.	Title	Href
1	Interactive effects of Andrographis paniculata extracts and cancer chemotherapeutic 5-Fluorouracil on cytochrome P450s expression in human hepatocellular carcinoma HepG2 cells	`Click`
2	Andrographis overcomes 5-fluorouracil-associated chemoresistance through inhibition of DKK1 in colorectal cancer. Carcinogenesis. 2021 Jun 21;42(6):814-825. doi: 10.1093/carcin/bgab027.	`Click`

No.

Title

Href

Interactive effects of Andrographis paniculata extracts and cancer chemotherapeutic 5-Fluorouracil on cytochrome P450s expression in human hepatocellular carcinoma HepG2 cells

Click

Andrographis overcomes 5-fluorouracil-associated chemoresistance through inhibition of DKK1 in colorectal cancer. Carcinogenesis. 2021 Jun 21;42(6):814-825. doi: 10.1093/carcin/bgab027.

Click

Name	Andrographolide
PubChem CID	5318517
Molecular Weight	350.4g/mol
Synonyms	17-hydro-9-dehydro-andrographolide, andrographolide, isoandrographolide
Formula	C₂₀H₃₀O₅
SMILES	CC12CCC(C(C1CCC(=C)C2CC=C3C(COC3=O)O)(C)CO)O
InChI	1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1
InChIKey	BOJKULTULYSRAS-OTESTREVSA-N
CAS Number	5508-58-7
ChEMBL ID	CHEMBL186141
ChEBI ID	CHEBI:65408
Herb ID	HBIN016019
Drug Bank ID	DB05767
KEGG ID	C20214
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	BoHe
Use Part	Aerial Parts
Habitat	JiangSu
Flavor	Pungent
Meridian Tropism	Lung, Liver
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Mentha 　　　　　　-->Species: Mentha haplocalyx

Chineses Pinyin	ChuanXinLian
Use Part	Aerial Parts
Habitat	JiangXi, HuNan, FuJian, GuangDong, GuangXi, SiChuan
Flavor	Bitter
Meridian Tropism	Heart, Lung, Large intestine, Bladder
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Acanthaceae 　　　　　-->Genus: Andrographis 　　　　　　-->Species: Andrographis paniculata

Chineses Pinyin	DangYao
Use Part	Whole Herb
Habitat	China
Flavor	Bitter
Meridian Tropism	Liver, Stomach, Large intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Gentianales 　　　　-->Family: Gentianaceae 　　　　　-->Genus: Swertia 　　　　　　-->Species: Swertia pseudochinensis

Chineses Pinyin	ChuangXinLian
Use Part	Heart; Lung; Large Intestine; Bladder
Habitat	JiangXi, HuNan, FuJian, GuangDong, GuangXi, SiChuan
Flavor	Bitter
Meridian Tropism	Dried aerial parts
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Acanthaceae 　　　　　-->Genus: Andrographis 　　　　　　-->Species: Andrographis paniculata

Pair Name	Andrographolide, Fluorouracil
Partner Name	Fluorouracil
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Gene Regulation	Up-regulation	Expression	CYP1A2	hsa1544
	Up-regulation	Expression	CYP3A4	hsa1576
	Down-regulation	Expression	CYP2D6	hsa1565
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
Result	Interactive effects of Andrographis paniculata extracts and cancer chemotherapeutic 5-Fluorouracil on cytochrome P450s expression in human hepatocellular carcinoma HepG2 cells

Pair Name	Andrographolide, Fluorouracil
Partner Name	Fluorouracil
Disease Info	[ICD-11: 2B91.Z]	Colorectal cancer		Investigative
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
Gene Regulation	Down-regulation	Expression	DKK1	hsa22943
Result	Our data provide novel evidence for andrographis-mediated reversal of 5FU resistance, highlighting its potential role as an adjunct to conventional chemotherapy in CRC.