Pair Name	Acteoside, Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Inhibition-->Angiogenesis
Gene Regulation	Up-regulation	Expression	TP53	hsa7157
	Down-regulation	Expression	KLK1	hsa3816
	Down-regulation	Expression	KLK2	hsa3817
	Down-regulation	Expression	KLK4	hsa9622
	Down-regulation	Expression	KLK9	hsa284366
	Down-regulation	Expression	KLK10	hsa5655
In Vitro Model	BEL-7404	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_6568
	HLF	Adult hepatocellular carcinoma	Homo sapiens (Human)	CVCL_2947
	JHH-7	Adult hepatocellular carcinoma	Homo sapiens (Human)	CVCL_2805
In Vivo Model	The BEL7404 cell suspensions were prepared (3×10⁶ cells) and injected subcutaneously into the right flank of athymic nude mice.
Result	Acteoside exerts an antitumor effect possibly through its up-regulation of p53 levels as well as inhibition of KLK expression and angiogenesis. Acteoside could be useful as an adjunct in the treatment of advanced HCC in the clinic.