5,7,4'-trihydroxy-8-methoxyflavone
| Name | 4'-Hydroxywogonin | ||
| PubChem CID | 5322078 | ||
| Molecular Weight | 300.26g/mol | ||
| Synonyms |
5,7,4'-trihydroxy-8-methoxyflavone |
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| Formula | C₁₆H₁₂O₆ | ||
| SMILES | COC1=C(C=C(C2=C1OC(=CC2=O)C3=CC=C(C=C3)O)O)O | ||
| InChI | 1S/C16H12O6/c1-21-15-12(20)6-10(18)14-11(19)7-13(22-16(14)15)8-2-4-9(17)5-3-8/h2-7,17-18,20H,1H3 | ||
| InChIKey | OEZZJTAJYYSQKM-UHFFFAOYSA-N | ||
| CAS Number | 57096-02-3 | ||
| ChEMBL ID | CHEMBL245712 | ||
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | HuangQin | ||
| Use Part | Root | ||
| Habitat | HeiLongJiang, LiaoNing, NeiMengGu, HeBei, HeNan, GanSu, Shaanxi, ShanXi, ShanDong, SiChuan | ||
| Flavor | Bitter | ||
| Meridian Tropism | Lung; Large Intestine; Stomach; Small Intestine; Gallbladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Scutellaria
-->Species: Scutellaria baicalensis
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| Pair Name | 4'-Hydroxywogonin, Wortmannin | |||
| Partner Name | Wortmannin | |||
| Disease Info | [ICD-11: 2B91.Z] | Colorectal cancer | Investigative | |
| Biological Phenomena | Inhibition-->Angiogenesis | |||
| Gene Regulation | Down-regulation | Phosphorylation | PIK3CA | hsa5290 |
| Down-regulation | Phosphorylation | AKT1 | hsa207 | |
| Down-regulation | Expression | VEGFA | hsa7422 | |
| In Vitro Model | SW620 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0547 |
| Result | 4'-HW decreased the viability and reduced angiogenesis in CRC, which was associated with downregulation of VEGF-A expression by disrupting the PI3K/AKT pathway. Our discoveries suggested 4'-HW as a promising anticancer agent against CRC targeting angiogenesis. | |||
