| Pair Name | Voacamine, Paclitaxel | ||
| Phytochemical Name | Voacamine (PubChem CID: 11953931 ) | ||
| Anticancer drug Name | Paclitaxel (PubChem CID: 36314 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Voacamine, Paclitaxel | |||
| Disease Info | [ICD-11: 2C73] | Ovarian cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Cleavage | PARP1 | hsa142 |
| Down-regulation | Expression | RELA | hsa5970 | |
| In Vitro Model | A2780 | Ovarian endometrioid adenocarcinoma | Homo sapiens (Human) | CVCL_0134 |
| Result | Our data show the specific effect of VOA which only works on drugs known to be substrates of P-gp. | |||
| No. | Title | Href |
|---|---|---|
| 1 | A natural product, voacamine, sensitizes paclitaxel-resistant human ovarian cancer cells. Toxicol Appl Pharmacol. 2022 Jan 1;434:115816. doi: 10.1016/j.taap.2021.115816. | Click |
