| Pair Name | Vitamin K3, Auranofin | ||
| Phytochemical Name | Vitamin K3 (PubChem CID: 4055 ) | ||
| Anticancer drug Name | Auranofin (PubChem CID: 24199313 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Vitamin K3, Auranofin | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Induction-->ROS accumulation | |||
| Gene Regulation | Up-regulation | Expression | TXNRD1 | hsa7296 |
| In Vitro Model | T98G | Glioblastoma | Homo sapiens (Human) | CVCL_0556 |
| U-87MG ATCC | Glioblastoma | Homo sapiens (Human) | CVCL_0022 | |
| LN-229 | Glioblastoma | Homo sapiens (Human) | CVCL_0393 | |
| Result | Our results identify TrxR1 as an attractive drug target and highlights AF as an off-patent drug candidate in GBM therapy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Menadione Potentiates Auranofin-Induced Glioblastoma Cell Death. Int J Mol Sci. 2022 Dec 11;23(24):15712. doi: 10.3390/ijms232415712. | Click |
