InterPAD - DETAILS

vinblastine, Vinblastin, 865-21-4, Vincaleucoblastin, Vincaleukoblastine, Vinblastina, Vincoblastine, Rozevin, Nincaluicolflastine, Vinblastinum, VR-8, Vinblastinum [INN-Latin], Velban, CCRIS 9002, HSDB 3263, NCI-C04842, UNII-5V9KLZ54CY, EINECS 212-734-0, 5V9KLZ54CY, NSC 47842, NDC 0002-1452-01, NSC-47842, (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE, CHEMBL159, DTXSID8021430, NSC 49842, (3aR-(3aalpha,4beta,5beta,5abeta,9(3R*,5S*,7R*,9S*),10bR*,13aalpha))-methyl 4-(acetyloxy)-3a-ethyl-9-(5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino(5,4-b)indol-9-yl)-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-1H-indolizino(8,1-cd)carbazole-5-carboxylate, 1H-Indolizino(8,1-cd)carbazole-5-carboxylic acid, 4-(acetyloxy)-3a-ethyl-9-(5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino(5,4-b)indol-9-yl)-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-, methyl ester, (3aR-(3aalpha,4beta,5beta,5abeta,9(3R*,5S*,7R*,9S*),10bR*,13aalpha))-, Vinblastina [DCIT], Vinblastinum (INN-Latin), Vinblastine [INN:BAN], methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate, VLB, VINBLASTINE [INN], cid_5388983, [3H]-Vinblastine, 1z2b, VINBLASTINE [MI], VINBLASTINE [HSDB], VINBLASTINE [VANDF], SCHEMBL3628, BIDD:PXR0201, BSPBio_001228, VINBLASTINE [WHO-DD], DTXCID801430, GTPL6851, L01CA01, 132142-72-4, methyl (3aR,3a1R,4R,5S,5aR,10bR)-4-acetoxy-3a-ethyl-9-((5S,7R,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate, BDBM50012278, NSC816570, AKOS015965500, CS-1336, DB00570, NSC-816570, NCGC00022585-04, NCGC00022585-05, NCGC00485975-02, 1ST15295, AC-24191, AS-15821, HY-17418, VinblastineVincaleukoblastine; Vinblastina, FT-0699091, EN300-19874057, VINDESINE SULFATE IMPURITY B [EP IMPURITY], VINCRISTINE SULFATE IMPURITY H [EP IMPURITY], BRD-K01188359-001-02-0, BRD-K01188359-065-02-5, (2alpha,2'beta,3alpha,5beta,19beta)-vincaleukoblastine, (2ALPHA,2''''BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE, (3AR-(3AALPHA,4BETA,5BETA,5ABETA,9(3R*,5S*,7R*,9S*),10BR*,13AALPHA))-METHYL 4-(ACETYLOXY)-3A-ETHYL-9-(5-ETHYL-1,4,5,6,7,8,9,10-OCTAHYDRO-5-HYDROXY-9- (METHOXYCARBONYL)-2H-3,7-METHANOAZACYCLOUNDECINO(5,4-B)INDOL-9-YL)- 3A,4,5,5A,6,11,12,13A-OCTAHYDRO-5-HYDROXY-8-METHOXY-6-METHYL-1H-INDOLIZINO (8,1-CD)CARBAZOLE-5-CARBOXYLATE, methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^{4,12}.0^{5,10}]nonadeca-4(12),5(10),6,8-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2,4,6,13-tetraene-10-carboxylate, VBL

Name	Vinblastine
PubChem CID	13342
Molecular Weight	811.0g/mol
Synonyms	vinblastine, Vinblastin, 865-21-4, Vincaleucoblastin, Vincaleukoblastine, Vinblastina, Vincoblastine, Rozevin, Nincaluicolflastine, Vinblastinum, VR-8, Vinblastinum [INN-Latin], Velban, CCRIS 9002, HSDB 3263, NCI-C04842, UNII-5V9KLZ54CY, EINECS 212-734-0, 5V9KLZ54CY, NSC 47842, NDC 0002-1452-01, NSC-47842, (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE, CHEMBL159, DTXSID8021430, NSC 49842, (3aR-(3aalpha,4beta,5beta,5abeta,9(3R,5S,7R,9S),10bR,13aalpha))-methyl 4-(acetyloxy)-3a-ethyl-9-(5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino(5,4-b)indol-9-yl)-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-1H-indolizino(8,1-cd)carbazole-5-carboxylate, 1H-Indolizino(8,1-cd)carbazole-5-carboxylic acid, 4-(acetyloxy)-3a-ethyl-9-(5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino(5,4-b)indol-9-yl)-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-, methyl ester, (3aR-(3aalpha,4beta,5beta,5abeta,9(3R,5S,7R,9S),10bR,13aalpha))-, Vinblastina [DCIT], Vinblastinum (INN-Latin), Vinblastine [INN:BAN], methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate, VLB, VINBLASTINE [INN], cid_5388983, [3H]-Vinblastine, 1z2b, VINBLASTINE [MI], VINBLASTINE [HSDB], VINBLASTINE [VANDF], SCHEMBL3628, BIDD:PXR0201, BSPBio_001228, VINBLASTINE [WHO-DD], DTXCID801430, GTPL6851, L01CA01, 132142-72-4, methyl (3aR,3a1R,4R,5S,5aR,10bR)-4-acetoxy-3a-ethyl-9-((5S,7R,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate, BDBM50012278, NSC816570, AKOS015965500, CS-1336, DB00570, NSC-816570, NCGC00022585-04, NCGC00022585-05, NCGC00485975-02, 1ST15295, AC-24191, AS-15821, HY-17418, VinblastineVincaleukoblastine; Vinblastina, FT-0699091, EN300-19874057, VINDESINE SULFATE IMPURITY B [EP IMPURITY], VINCRISTINE SULFATE IMPURITY H [EP IMPURITY], BRD-K01188359-001-02-0, BRD-K01188359-065-02-5, (2alpha,2'beta,3alpha,5beta,19beta)-vincaleukoblastine, (2ALPHA,2''''BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE, (3AR-(3AALPHA,4BETA,5BETA,5ABETA,9(3R,5S,7R,9S),10BR*,13AALPHA))-METHYL 4-(ACETYLOXY)-3A-ETHYL-9-(5-ETHYL-1,4,5,6,7,8,9,10-OCTAHYDRO-5-HYDROXY-9- (METHOXYCARBONYL)-2H-3,7-METHANOAZACYCLOUNDECINO(5,4-B)INDOL-9-YL)- 3A,4,5,5A,6,11,12,13A-OCTAHYDRO-5-HYDROXY-8-METHOXY-6-METHYL-1H-INDOLIZINO (8,1-CD)CARBAZOLE-5-CARBOXYLATE, methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^{4,12}.0^{5,10}]nonadeca-4(12),5(10),6,8-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2,4,6,13-tetraene-10-carboxylate, VBL
Drug Type	Small molecule
Formula	C₄₆H₅₈N₄O₉
SMILES	CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
InChI	1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1
InChIKey	JXLYSJRDGCGARV-CFWMRBGOSA-N
CAS Number	865-21-4
ChEMBL ID	CHEMBL159
TTD ID	D0W9MM
Drug Bank ID	DB00570
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Pair Name	Emodin, Vinblastine
Partner Name	Emodin
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation	Down-regulation	Activity	ATM	hsa472
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Activity	CASP3	hsa836
	Up-regulation	Activity	CASP7	hsa840
	Up-regulation	Expression	ROS1	hsa6098
In Vitro Model	HeLa	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0030
Result	Emodin Sensitizes Cervical Cancer Cells to Vinblastine by Inducing Apoptosis and Mitotic Death