triptonide
| Name | Triptonide | ||
| PubChem CID | 65411 | ||
| Molecular Weight | 358.4g/mol | ||
| Synonyms |
triptonide |
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| Formula | C₂₀H₂₂O₆ | ||
| SMILES | CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2=O)O7)COC6=O)C | ||
| InChI | 1S/C20H22O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14H,4-7H2,1-3H3/t11-,12-,13-,14-,17-,18-,19+,20+/m0/s1 | ||
| InChIKey | SWOVVKGLGOOUKI-ZHGGVEMFSA-N | ||
| CAS Number | 38647-11-9 | ||
| ChEMBL ID | CHEMBL205190 | ||
| ChEBI ID | CHEBI:132267 | ||
| Herb ID | HBIN047177 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | KunMingShanHaiTang | ||
| Use Part | Root | ||
| Habitat | ZheJiang, JiangXi, HuNan, SiChuan, GuiZhou, YunNan | ||
| Flavor | Bitter, Pungent | ||
| Meridian Tropism | Liver, Spleen, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Celastrales
-->Family: Celastraceae
-->Genus: Tripterygium
-->Species: Tripterygium hypoglaucum
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| Chineses Pinyin | LeiGongTeng | ||
| Use Part | Root, Leaf, Flower | ||
| Habitat | HuNan, JiangXi, ZheJiang, FuJian, GuangDong, GuiZhou, YunNan, HaiNan, XiZang, TaiWan, ChongQing | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Heart, Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Celastrales
-->Family: Celastraceae
-->Genus: Tripterygium
-->Species: Tripterygium wilfordii
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| Pair Name | Triptonide, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2B72] | Gastric cancer | Investigative | |
| Biological Phenomena | Inhibition-->Autophagy | |||
| Gene Regulation | Up-regulation | Expression | BECN1 | hsa8678 |
| Up-regulation | Expression | MAP1LC3A | hsa84557 | |
| Up-regulation | Expression | MAP1LC3B | hsa81631 | |
| Down-regulation | Expression | SQSTM1 | hsa8878 | |
| In Vitro Model | MGC-803/DDP | Gastric mucinous adenocarcinoma | Homo sapiens (Human) | CVCL_UI42 |
| In Vivo Model | A total of 32 nude mice were subcutaneously injected with AGS/DDP cells. | |||
| Result | Triptonide Restore Cisplatin Sensitivity in Drug-Resistant Gastric Cancer Cells by Inhibiting Protective Autophagy | |||
