| Pair Name | Tricetin, ERK inhibitor | ||
| Phytochemical Name | Tricetin (PubChem CID: 5281701 ) | ||
| Anticancer drug Name | ERK inhibitor (PubChem CID: / ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Tricetin, ERK inhibitor | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Inhibition-->Cell metastasis | |||
| Gene Regulation | Down-regulation | Expression | MMP2 | hsa4313 |
| Down-regulation | Expression | SP1 | hsa6667 | |
| Result | SP-1 is an important target of tricetin for suppressing MMP-2-mediated cell motility in GBM cells, and a combination of tricetin and an ERK inhibitor may be a good strategy for preventing GBM invasion. | |||
| No. | Title | Href |
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| 1 | Tricetin suppresses the migration/invasion of human glioblastoma multiforme cells by inhibiting matrix metalloproteinase-2 through modulation of the expression and transcriptional activity of specificity protein 1. Expert Opin Ther Targets. 2015;19(10):1293-306. doi: 10.1517/14728222.2015.1075509. | Click |
