Pair Name	Thymoquinone, Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	CDH13	hsa1012
	Down-regulation	Expression	NFKB1	hsa4790
In Vitro Model	NCI-H460	Lung large cell carcinoma	Homo sapiens (Human)	CVCL_0459
	NCI-H146	Lung small cell carcinoma	Homo sapiens (Human)	CVCL_1473
In Vivo Model	Xenografts were obtained by injecting NCI-H460 2×10⁶ cells subcutaneously into the right flank of each female SCID mice (age 5-6 weeks old).
Result	Thymoquinone combined with cisplatin showed synergistic anticancer activity by down-regulating NF-kappaB

Pair Name	Thymoquinone, Cisplatin
Disease Info	[ICD-11: 2C94]	Bladder cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
In Vitro Model	5637	Bladder carcinoma	Homo sapiens (Human)	CVCL_0126
Result	TQ significantly increased the cytotoxicity of CDDP in 5637 cells and induced apoptosis by down-regulation of the Bcl-2. Therefore, TQ and CDDP might be an effective therapeutic combination for TCC bladder cancer treatment.