Pair Name | Taurine, Temozolomide | ||
Phytochemical Name | Taurine (PubChem CID: 1123 ) | ||
Anticancer drug Name | Temozolomide (PubChem CID: 5394 ) | ||
Structure of Phytochemical |
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2D
MOL
3D
MOL
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Structure of Anticancer Drug |
Download
2D
MOL
3D
MOL
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Pair Name | Taurine, Temozolomide | |||
Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
Up-regulation | Expression | BAX | hsa581 | |
Down-regulation | Expression | BCL2 | hsa596 | |
In Vitro Model | U-251MG | Astrocytoma | Homo sapiens (Human) | CVCL_0021 |
Result | The study showed that the combination between TMZ and TAU has a potential in anticancer properties against U-251 MG manifested by the induction of G2/M arrest and apoptosis. These results suggest that this combination may be useful to enhance the efficacy and reduce some adverse events of GBM treatment in the future. |
No. | Title | Href |
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1 | Synergistic Effects of Taurine and Temozolomide Via Cell Proliferation Inhibition and Apoptotic Induction on U-251 MG Human Glioblastoma Cells. Asian Pac J Cancer Prev. 2021 Dec 1;22(12):4001-4009. doi: 10.31557/APJCP.2021.22.12.4001. | Click |