Taufon, Tauphon, Taurine, Taurine Hydrochloride, Taurine Zinc Salt (2:1), Taurine, Monopotassium Salt
| Name | Taurine | ||
| PubChem CID | 1123 | ||
| Molecular Weight | 125.15g/mol | ||
| Synonyms |
Taufon, Tauphon, Taurine, Taurine Hydrochloride, Taurine Zinc Salt (2:1), Taurine, Monopotassium Salt |
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| Formula | C₂H₇NO₃S | ||
| SMILES | C(CS(=O)(=O)O)N | ||
| InChI | 1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) | ||
| InChIKey | XOAAWQZATWQOTB-UHFFFAOYSA-N | ||
| CAS Number | 107-35-7 | ||
| ChEMBL ID | CHEMBL239243 | ||
| ChEBI ID | CHEBI:15891 | ||
| Herb ID | HBIN045582 | ||
| Drug Bank ID | DB01956 | ||
| KEGG ID | C00245 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | BaDou | ||
| Use Part | Seed, Root, Leaf | ||
| Habitat | SiChuan, HuNan, HuBei, YunNan, GuiZhou, GuangXi, GuangDong, FuJian, TaiWan, ZheJiang, JiangSu | ||
| Flavor | Pungent | ||
| Meridian Tropism | Stomach, Large intestine | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Malpighiales
-->Family: Euphorbiaceae
-->Genus: Croton
-->Species: Croton tiglium
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| Chineses Pinyin | KunBu | ||
| Use Part | Dried Thallus | ||
| Habitat | ShanDong, LiaoNing, ZheJiang | ||
| Flavor | Salty | ||
| Meridian Tropism | Liver, Stomach, Kidney | ||
| Chineses Pinyin | YinChen | ||
| Use Part | Whole Herb | ||
| Habitat | China | ||
| Flavor | Bitter, Pungent | ||
| Meridian Tropism | Spleen, Stomach, Liver, Gallbladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asterales
-->Family: Asteraceae
-->Genus: Artemisia
-->Species: Artemisia scoparia
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| Chineses Pinyin | DiGuPi | ||
| Use Part | Root Bark | ||
| Habitat | China | ||
| Flavor | Sweet | ||
| Meridian Tropism | Lung, Liver, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Solanales
-->Family: Solanaceae
-->Genus: Lycium
-->Species: Lycium chinense
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| Chineses Pinyin | GouQiZi | ||
| Use Part | Fruit | ||
| Habitat | HeBei, NeiMengGu, Shaanxi | ||
| Flavor | Sweet | ||
| Meridian Tropism | Liver, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Solanales
-->Family: Solanaceae
-->Genus: Lycium
-->Species: Lycium barbarum
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| Chineses Pinyin | GouQiYe | ||
| Use Part | Leaf | ||
| Habitat | NingXia, Shaanxi, GanSu, QingHai, NingXia, XinJiang | ||
| Flavor | Bitter, Sweet | ||
| Meridian Tropism | Liver, Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Solanales
-->Family: Solanaceae
-->Genus: Lycium
-->Species: Lycium barbarum
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| Chineses Pinyin | MaoLianHao | ||
| Use Part | Stem, Leaf | ||
| Habitat | HeiLongJiang, JiLin, LiaoNing, SiChuan, GuiZhou, YunNan, XiZang, ChongQing, XinJiang | ||
| Flavor | Bitter | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asterales
-->Family: Asteraceae
-->Genus: Artemisia
-->Species: Artemisia vestita
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| Chineses Pinyin | NiuHuang | ||
| Use Part | Gallstone | ||
| Flavor | Sweet | ||
| Meridian Tropism | Liver; Heart | ||
| Species |
>Kingdom: Metazoa
-->Phylum: Chordata
-->Class: Mammalia
-->Order: Primates
-->Family: Hominidae
-->Genus: Homo
-->Species: Homo sapiens
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| Pair Name | Taurine, Temozolomide | |||
| Partner Name | Temozolomide | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| In Vitro Model | U-251MG | Astrocytoma | Homo sapiens (Human) | CVCL_0021 |
| Result | The study showed that the combination between TMZ and TAU has a potential in anticancer properties against U-251 MG manifested by the induction of G2/M arrest and apoptosis. These results suggest that this combination may be useful to enhance the efficacy and reduce some adverse events of GBM treatment in the future. | |||
