13,14-didehydro-matridin-15-one, 13,14-didehydromatridin-15-one hydrobromide, matridin-15-one, 13,14-didehydro-, monohydrobromide, sophocarpine, sophocarpine hydrobromide
| Name | Sophocarpine | ||
| PubChem CID | 115269 | ||
| Molecular Weight | 246.35g/mol | ||
| Synonyms |
13,14-didehydro-matridin-15-one, 13,14-didehydromatridin-15-one hydrobromide, matridin-15-one, 13,14-didehydro-, monohydrobromide, sophocarpine, sophocarpine hydrobromide |
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| Formula | C₁₅H₂₂N₂O | ||
| SMILES | C1CC2CN3C(CC=CC3=O)C4C2N(C1)CCC4 | ||
| InChI | 1S/C15H22N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h1,7,11-13,15H,2-6,8-10H2/t11-,12+,13+,15-/m0/s1 | ||
| InChIKey | AAGFPTSOPGCENQ-JLNYLFASSA-N | ||
| CAS Number | 6483-15-4 | ||
| ChEMBL ID | CHEMBL377725 | ||
| ChEBI ID | CHEBI:228910 | ||
| Herb ID | HBIN044342 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | Huai | ||
| Use Part | Flower Bud, Flower, Fruit | ||
| Habitat | BeiJing, TianJin, HeBei, ShanXi, NeiMengGu | ||
| Flavor | Bitter | ||
| Meridian Tropism | Liver, Large intestine | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Styphnolobium
-->Species: Styphnolobium japonicum
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| Chineses Pinyin | KuShen | ||
| Use Part | Root | ||
| Habitat | China | ||
| Flavor | Bitter | ||
| Meridian Tropism | Heart, Liver, Stomach, Large intestine, Bladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Sophora
-->Species: Sophora flavescens
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| Chineses Pinyin | KuDouZi | ||
| Use Part | Whole Grass, Seed | ||
| Habitat | NeiMengGu, XinJiang, XiZang | ||
| Flavor | Bitter | ||
| Meridian Tropism | Heart, Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Sophora
-->Species: Sophora alopecuroides
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| Chineses Pinyin | ShanDouGen | ||
| Use Part | Root, Rhizome | ||
| Habitat | GuangXi | ||
| Flavor | Bitter | ||
| Meridian Tropism | Lung, Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Sophora
-->Species: Sophora tonkinensis
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| Chineses Pinyin | WuTou | ||
| Use Part | Tuberoid | ||
| Habitat | SiChuan | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Heart, Liver, Spleen, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Ranunculales
-->Family: Ranunculaceae
-->Genus: Aconitum
-->Species: Aconitum carmichaelii
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| Chineses Pinyin | BaiCiHua | ||
| Use Part | Root | ||
| Habitat | YunNan, SiChuan, GuiZhou, Shaanxi, GanSu, HeNan, ShanXi, HeBei | ||
| Flavor | Bitter | ||
| Meridian Tropism | Liver, Bladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Sophora
-->Species: Sophora davidii
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| Chineses Pinyin | BaoShanWuTou | ||
| Use Part | Tuberoid | ||
| Habitat | YunNan | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Ranunculales
-->Family: Ranunculaceae
-->Genus: Aconitum
-->Species: Aconitum nagarum
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| Chineses Pinyin | DuoGenWuTou | ||
| Use Part | Tuberoid | ||
| Habitat | XinJiang | ||
| Flavor | Pungent | ||
| Meridian Tropism | Heart, Liver, Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Ranunculales
-->Family: Ranunculaceae
-->Genus: Aconitum
-->Species: Aconitum karakolicum
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| Pair Name | Sophocarpine, Oxaliplatin | |||
| Partner Name | Oxaliplatin | |||
| Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
| Biological Phenomena | Inhibition-->Epithelial-mesenchymal transition | |||
| Gene Regulation | Up-regulation | Expression | CDH1 | hsa999 |
| Down-regulation | Expression | CDH2 | hsa1000 | |
| Down-regulation | Expression | VIM | hsa7431 | |
| In Vitro Model | LoVo | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0399 |
| In Vivo Model | Liver metastasis nude mouse models (n = 40) were prepared by the injection of LoVo cells suspended in PBS into the center point of the spleen using a 31-gauge needle. | |||
| Result | Sophocarpine can enhance the inhibiting effect of oxaliplatin on colon cancer liver metastasis-in vitro and in vivo | |||
