Pair Name	Sinomenium acutum, Fluorouracil
Disease Info	[ICD-11: 2B70]	Esophageal cancer		Investigative
Biological Phenomena	Induction-->Mitochondria-mediated apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
In Vitro Model	Eca-109	Esophageal squamous cell carcinoma	Homo sapiens (Human)	CVCL_6898
In Vivo Model	Esophageal carcinoma tumors were established in male BALB/c nude mice (4-6 wk, Laboratory Animal Central of Wuhan University) by serial subcutaneous transplantation of Eca-109 cells (1×10⁷ cells/mouse).
Result	The combined effects of SIN and 5-FU on esophageal carcinoma were superior to those of the individual compounds, and the drug combination did not increase the side effects of chemotherapy.