InterPAD - DETAILS

4-hydroxy-3,5-dimethoxycinnamate choline, sinapine, sinapine bisulphate, sinapine, monosulfate salt, sinapine, thiocyanate salt

No.	Title	Href
1	Sinapine reverses multi-drug resistance in MCF-7/dox cancer cells by downregulating FGFR4/FRS2α-ERK1/2 pathway-mediated NF-κB activation. Phytomedicine. 2016 Mar 15;23(3):267-73. doi: 10.1016/j.phymed.2015.12.017.	`Click`

No.

Title

Href

Sinapine reverses multi-drug resistance in MCF-7/dox cancer cells by downregulating FGFR4/FRS2α-ERK1/2 pathway-mediated NF-κB activation. Phytomedicine. 2016 Mar 15;23(3):267-73. doi: 10.1016/j.phymed.2015.12.017.

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Name	Sinapine
PubChem CID	5280385
Molecular Weight	310.36g/mol
Synonyms	4-hydroxy-3,5-dimethoxycinnamate choline, sinapine, sinapine bisulphate, sinapine, monosulfate salt, sinapine, thiocyanate salt
Formula	C₁₆H₂₄NO₅+
SMILES	C[N+](C)(C)CCOC(=O)C=CC1=CC(=C(C(=C1)OC)O)OC
InChI	1S/C16H23NO5/c1-17(2,3)8-9-22-15(18)7-6-12-10-13(20-4)16(19)14(11-12)21-5/h6-7,10-11H,8-9H2,1-5H3/p+1
InChIKey	HUJXHFRXWWGYQH-UHFFFAOYSA-O
CAS Number	18696-26-9
ChEBI ID	CHEBI:16353
Herb ID	HBIN044064
KEGG ID	C00933
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	BaiJieZi
Use Part	Seed
Habitat	LiaoNing, ShanXi, XinJiang, ShanDong, AnHui, SiChuan, YunNan
Flavor	Pungent
Meridian Tropism	Lung, Liver, Spleen, Stomach, Pericardium
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Brassicales 　　　　-->Family: Brassicaceae 　　　　　-->Genus: Sinapis 　　　　　　-->Species: Sinapis alba

Chineses Pinyin	BaiJie
Use Part	Seed
Habitat	LiaoNing, ShanXi, XinJiang, ShanDong, AnHui, SiChuan, YunNan
Flavor	Pungent
Meridian Tropism	Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Brassicales 　　　　-->Family: Brassicaceae 　　　　　-->Genus: Sinapis 　　　　　　-->Species: Sinapis alba

Pair Name	Sinapine, Doxorubicin
Partner Name	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Gene Regulation	Down-regulation	Expression	ABCB1	hsa5243
	Down-regulation	Expression	FOXP3	hsa50943
	Up-regulation	Expression	IL17A	hsa3605
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
Result	Our findings indicated that sinapine played an important role in the downregulation of MDR1 expression through suppression of fibroblast growth factor receptor (FGFR)4/FRS2α-ERK1/2 mediated NF-κB activation in MCF-7/dox cancer cells.