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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Silibinin, Doxorubicin
Phytochemical Name Silibinin (PubChem CID: 31553 )
Anticancer drug Name Doxorubicin (PubChem CID: 31703 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 141
Ref_1
Pair Name Silibinin, Doxorubicin
Disease Info [ICD-11: 2C12] Hepatocellular carcinoma Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation Up-regulation Expression CDC25C hsa995
Down-regulation Activity CDK1 hsa983
Up-regulation Expression CHEK1 hsa1111
Up-regulation Expression MS4A1 hsa931
In Vitro Model Hep-G2 Hepatoblastoma Homo sapiens (Human) CVCL_0027
In Vivo Model An orthotopic rat model of HCC was used, in which subcutaneously injected Morris hepatoma (MH)-3924A cells (5×10⁶) in syngeneic ACI rats (Harlan, USA) led to formation of a subcutaneous tumor within 14 days.
Result Inhibitory effects of Silibinin combined with doxorubicin in hepatocellular carcinoma; an in vivo study
03. Reference
No. Title Href
1 Inhibitory effects of Silibinin combined with doxorubicin in hepatocellular carcinoma; an in vivo study. J BUON. 2016 Jul-Aug;21(4):917-924. Click
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