InterPAD - DETAILS

(+--)-gamma-schizandrin, (-)-gomisin N, Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxole, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6R,7S,13aR)-, benzo(3,4)cycloocta(1,2-F)(1,3)benzodioxole, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6R,7S,13AS)-, gamma-schizandrin, gomisin N, schisandrin B, schizandrin B, wuweizisu b

No.	Title	Href
1	The potential effect of Schisandrin-B combination with panitumumab in wild-type and mutant colorectal cancer cell lines: Role of apoptosis and autophagy. J Biochem Mol Toxicol. 2023 May;37(5):e23324. doi: 10.1002/jbt.23324.	`Click`

No.

Title

Href

The potential effect of Schisandrin-B combination with panitumumab in wild-type and mutant colorectal cancer cell lines: Role of apoptosis and autophagy. J Biochem Mol Toxicol. 2023 May;37(5):e23324. doi: 10.1002/jbt.23324.

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Name	Schisandrin B
PubChem CID	108130
Molecular Weight	400.5g/mol
Synonyms	(+--)-gamma-schizandrin, (-)-gomisin N, Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxole, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6R,7S,13aR)-, benzo(3,4)cycloocta(1,2-F)(1,3)benzodioxole, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6R,7S,13AS)-, gamma-schizandrin, gomisin N, schisandrin B, schizandrin B, wuweizisu b
Formula	C₂₃H₂₈O₆
SMILES	CC1CC2=CC3=C(C(=C2C4=C(C(=C(C=C4CC1C)OC)OC)OC)OC)OCO3
InChI	1S/C23H28O6/c1-12-7-14-9-16(24-3)20(25-4)22(26-5)18(14)19-15(8-13(12)2)10-17-21(23(19)27-6)29-11-28-17/h9-10,12-13H,7-8,11H2,1-6H3
InChIKey	RTZKSTLPRTWFEV-UHFFFAOYSA-N
CAS Number	61281-37-6
ChEMBL ID	CHEMBL479488
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	WuWeiZi
Use Part	Fruit
Habitat	HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, HuBei, HuNan, JiangXi, SiChuan
Flavor	Sour; Sweet
Meridian Tropism	Lung; Heart; Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Austrobaileyales 　　　　-->Family: Schisandraceae 　　　　　-->Genus: Schisandra 　　　　　　-->Species: Schisandra chinensis

Pair Name	Schisandrin B, Panitumumab
Partner Name	Panitumumab
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Biological Phenomena	Induction-->Autophagy
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BECN1	hsa8678
	Up-regulation	Activity	CASP3	hsa836
	Down-regulation	Expression	MAP1LC3B	hsa81631
In Vitro Model	Caco-2	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0025
	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
	HT-29	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0320
Result	This novel combination therapy against CRC, allows the reduction of panitumumab dose to guard against its adverse effects.