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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Resveratrol, Gemcitabine
Phytochemical Name Resveratrol (PubChem CID: 445154 )
Anticancer drug Name Gemcitabine (PubChem CID: 60750 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 380
Ref_1
Pair Name Resveratrol, Gemcitabine
Disease Info [ICD-11: 2C10.Z] Pancreatic cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression VEGFA hsa7422
Up-regulation Phosphorylation GSK3B hsa2932
In Vitro Model Capan-2 Pancreatic ductal adenocarcinoma Homo sapiens (Human) CVCL_0026
MIA PaCa-2 Pancreatic ductal adenocarcinoma Homo sapiens (Human) CVCL_0428
PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens (Human) CVCL_0480
In Vivo Model 5×10⁶ MiaPaCa2 cells were suspended in DMEM medium and transplanted subcutaneously in each nude mouse.
Result These results suggest that VEGF-B signaling pathway plays an important role in the development of PaCa and combination of GEM and RSV would be a promising modality for clinical PaCa therapy.
03. Reference
No. Title Href
1 Gemcitabine potentiates anti-tumor effect of resveratrol on pancreatic cancer via down-regulation of VEGF-B. J Cancer Res Clin Oncol. 2021 Jan;147(1):93-103. doi: 10.1007/s00432-020-03384-7. Click
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