Pair Name | RA-V, Doxorubicin | ||
Phytochemical Name | RA-V (PubChem CID: 13361282 ) | ||
Anticancer drug Name | Doxorubicin (PubChem CID: 31703 ) | ||
Structure of Phytochemical |
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2D
MOL
3D
MOL
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Structure of Anticancer Drug |
Download
2D
MOL
3D
MOL
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Pair Name | RA-V, Doxorubicin | |||
Disease Info | [ICD-11: 2C77] | Cervical cancer | Investigative | |
Biological Phenomena | Induction-->Mitochondria-mediated apoptosis | |||
Gene Regulation | Up-regulation | Expression | CYCS | hsa54205 |
In Vitro Model | HeLa | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_0030 |
In Vivo Model | The HeLa cells (5×10⁶ cells) were transplanted subcutaneously into the 8-week female BALB/c nude mice by using a stereotactic fixation device with mouse adaptor. | |||
Result | This work represents a versatile strategy for precise combination therapy against resistant tumor with spatiotemporal control, and provides a potential tool for Cyt c-related apoptotic studies. |
No. | Title | Href |
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1 | Sequential Delivery of Cyclopeptide RA-V and Doxorubicin for Combination Therapy on Resistant Tumor and In Situ Monitoring of Cytochrome c Release. Theranostics. 2017 Aug 23;7(15):3781-3793. doi: 10.7150/thno.20892. | Click |