| Pair Name | Piceatannol, Shikonin | ||
| Phytochemical Name | Piceatannol (PubChem CID: 667639 ) | ||
| Anticancer drug Name | Shikonin (PubChem CID: 479503 ) | ||
| Structure of Phytochemical |
|
Download
2D
MOL
3D
MOL
|
|
| Structure of Anticancer Drug |
|
Download
2D
MOL
3D
MOL
|
|
| Pair Name | Piceatannol, Shikonin | |||
| Disease Info | [ICD-11: 2A00-2F9Z] | Solid tumour or cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Cleavage | PARP1 | hsa142 |
| In Vitro Model | HL-60 | Adult acute myeloid leukemia | Homo sapiens (Human) | CVCL_0002 |
| NCI-H522 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_1567 | |
| Result | These results indicate that concomitant use of low-dose shikonin potentiates piceatannol-induced apoptosis of GLO I-dependent cancer cells by augmenting methylglyoxal accumulation. | |||
| No. | Title | Href |
|---|---|---|
| 1 | The PKM2 inhibitor shikonin enhances piceatannol-induced apoptosis of glyoxalase I-dependent cancer cells. Genes Cells. 2024 Jan;29(1):52-62. doi: 10.1111/gtc.13084. | Click |
