| Name | Glycodelin | ||
| UniProt ID | PAEP_HUMAN | ||
| Gene Name | PAEP | ||
| Gene ID | 5047 | ||
| Synonyms |
PAEP, GD, GdA, GdF, GdS, PAEG, PEP, PP14, ZIF-1
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| Sequence |
MLCLLLTLGVALVCGVPAMDIPQTKQDLELPKLAGTWHSMAMATNNISLMATLKAPLRVH
ITSLLPTPEDNLEIVLHRWENNSCVEKKVLGEKTENPKKFKINYTVANEATLLDTDYDNF LFLCLQDTTTPIQSMMCQYLARVLVEDDEIMQGFIRAFRPLPRHLWYLLDLKQMEEPCRF |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa5047 | ||
| Pfam | PF00061; PF19481 | ||
| Pair Name | Gambogic Acid, Fluorouracil | |||
| Phytochemical | Gambogic Acid | |||
| Drug | Fluorouracil | |||
| Disease Info | [ICD-11: 2B72.Z] | Gastric cancer | Investigative | |
| Regulate Info | Up-regulation | Glycodelin | Cleavage | |
| Result | Our data showed that GA attenuated 5-FU-induced apoptosis by modulating metabolic enzymes of 5-FU and the antigastric cancer effect of two drugs combination was much stronger than that of GA or 5-FU alone. | |||
| Pair Name | Beta-Elemene, Oxaliplatin | |||
| Phytochemical | Beta-Elemene | |||
| Drug | Oxaliplatin | |||
| Disease Info | [ICD-11: 2B91.Z] | Colorectal cancer | Investigative | |
| Regulate Info | Up-regulation | Glycodelin | Cleavage | |
| Result | Our findings show that β-elemene can block the reduction of CTR1 resulting from oxaliplatin treatment, and therefore has a synergistic anti-HCC effect with oxaliplatin by enhancing cellular uptake of oxaliplatin. The synergistic effects of β-elemene and oxaliplatin deserve further evaluation in clinical settings. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Synergistic effect of 5-fluorouracil with gambogic acid on BGC-823 human gastric carcinoma. Toxicology. 2009 Feb 4;256(1-2):135-40. doi: 10.1016/j.tox.2008.11.014. | Click |
| 2 | β-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1. Sci Rep. 2016 Feb 12;6:21010. doi: 10.1038/srep21010. | Click |
