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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Obovatol, Docetaxel
Phytochemical Name Obovatol (PubChem CID: 100771 )
Anticancer drug Name Docetaxel (PubChem CID: 148124 )
Structure of
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Structure of
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 346
Ref_1
Pair Name Obovatol, Docetaxel
Disease Info [ICD-11: 2B90.Z] Colon cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression NFKB1 hsa4790
In Vitro Model LNCaP Prostate carcinoma Homo sapiens (Human) CVCL_0395
PC-3 Prostate carcinoma Homo sapiens (Human) CVCL_0035
SW620 Colon adenocarcinoma Homo sapiens (Human) CVCL_0547
HCT 116 Colon carcinoma Homo sapiens (Human) CVCL_0291
Result These results indicate that obovatol augments cell growth inhibition by chemotherapeutics through inactivation of NF-kappaB and suggest that obovatol may have therapeutic advantages in the combination treatment with other chemotherapeutics.
03. Reference
No. Title Href
1 Obovatol enhances docetaxel-induced prostate and colon cancer cell death through inactivation of nuclear transcription factor-kappaB. J Pharmacol Sci. 2009 Oct;111(2):124-36. doi: 10.1254/jphs.09048fp. Click
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