| Pair Name | Norizalpinin, Fluorouracil | ||
| Phytochemical Name | Norizalpinin (PubChem CID: 5281616 ) | ||
| Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
| Structure of Phytochemical |
|
Download
2D
MOL
3D
MOL
|
|
| Structure of Anticancer Drug |
|
Download
2D
MOL
3D
MOL
|
|
| Pair Name | Norizalpinin, Fluorouracil | |||
| Disease Info | [ICD-11: 2B70] | Esophageal cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Down-regulation | Expression | IL1B | hsa3553 | |
| Down-regulation | Expression | NLRP3 | hsa114548 | |
| In Vitro Model | Eca-109 | Esophageal squamous cell carcinoma | Homo sapiens (Human) | CVCL_6898 |
| OE19 | Esophageal adenocarcinoma | Homo sapiens (Human) | CVCL_1622 | |
| Result | Our results indicated that galangin played a synergistic anticancer role through NLRP3 inflammasome inhibition when paired with FU-5. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Galangin Enhances Anticancer Efficacy of 5-Fluorouracil in Esophageal Cancer Cells and Xenografts Through NLR Family Pyrin Domain Containing 3 (NLRP3) Downregulation. Med Sci Monit. 2021 Dec 17;27:e931630. doi: 10.12659/MSM.931630. | Click |
