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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Methylselenocysteine, Etoposide
Phytochemical Name Methylselenocysteine (PubChem CID: 147004 )
Anticancer drug Name Etoposide (PubChem CID: 36462 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 897
Ref_1
Pair Name Methylselenocysteine, Etoposide
Disease Info [ICD-11: 2C77] Cervical cancer Investigative
Biological Phenomena Induction-->Gap junction activity
Gene Regulation Up-regulation Expression GJB1 hsa2705
Up-regulation Expression GJB2 hsa2706
In Vitro Model HeLa Human papillomavirus-related cervical adenocarcinoma Homo sapiens (Human) CVCL_0030
Result We provide the novel finding that MSC increases etoposide-mediated cytotoxicity by enhancing GJ activity, due to elevated Cx expression through a GSH-dependent posttranscriptional mechanism. More generally, the study highlights potential benefit of the combination of GJ modulators and chemotherapeutic agents in anticancer treatment.
03. Reference
No. Title Href
1 Methylselenocysteine Potentiates Etoposide-Induced Cytotoxicity by Enhancing Gap Junction Activity. Biol Pharm Bull. 2022;45(4):467-476. doi: 10.1248/bpb.b21-00893. Click
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