| Pair Name | Methoxsalen, Temozolomide | ||
| Phytochemical Name | Methoxsalen (PubChem CID: 4114 ) | ||
| Anticancer drug Name | Temozolomide (PubChem CID: 5394 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Methoxsalen, Temozolomide | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Inhibition-->Cell proliferation | |||
| Gene Regulation | Down-regulation | Expression | MMP2 | hsa4313 |
| In Vitro Model | U-251MG | Astrocytoma | Homo sapiens (Human) | CVCL_0021 |
| LN-229 | Glioblastoma | Homo sapiens (Human) | CVCL_0393 | |
| Result | We showed a marked antitumor effect of 4MU on GBM cells alone and in combination with chemotherapy and proved, for the first time, the effect of 4MU on TMZ-resistant models, demonstrating that 4MU would be a potential therapeutic alternative for improving GBM therapy even on TMZ-refractory patients. | |||
| No. | Title | Href |
|---|---|---|
| 1 | 4-Methylumbelliferone enhances the effects of chemotherapy on both temozolomide-sensitive and resistant glioblastoma cells. Sci Rep. 2023 Jun 8;13(1):9356. doi: 10.1038/s41598-023-35045-3. | Click |
