(1Z,5S,5aS,8Z,10bS,10cS)-1,8-dibutylidene-5,5a,6,7,8,10b-hexahydro-1H-5,10c-ethanonaphtho(1,2-c:7,8-c')difuran-3,10-dione, levistilide A
| Name | Levistolide A | ||
| PubChem CID | 70698035 | ||
| Molecular Weight | 380.5g/mol | ||
| Synonyms |
(1Z,5S,5aS,8Z,10bS,10cS)-1,8-dibutylidene-5,5a,6,7,8,10b-hexahydro-1H-5,10c-ethanonaphtho(1,2-c:7,8-c')difuran-3,10-dione, levistilide A |
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| Formula | C₂₄H₂₈O₄ | ||
| SMILES | CCCC=C1C2=C(C3C(CC2)C4CCC35C(=C4)C(=O)OC5=CCCC)C(=O)O1 | ||
| InChI | 1S/C24H28O4/c1-3-5-7-18-16-10-9-15-14-11-12-24(21(15)20(16)23(26)27-18)17(13-14)22(25)28-19(24)8-6-4-2/h7-8,13-15,21H,3-6,9-12H2,1-2H3/b18-7-,19-8-/t14-,15+,21-,24+/m1/s1 | ||
| InChIKey | UBBRXVRQZJSDAK-ZJHGLIIDSA-N | ||
| CAS Number | 88182-33-6 | ||
| ChEBI ID | CHEBI:68231 | ||
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | ChuanXiong | ||
| Use Part | Rhizome | ||
| Habitat | SiChuan | ||
| Flavor | Pungent | ||
| Meridian Tropism | Liver, Gallbladder, Pericardium | ||
| Chineses Pinyin | DangGui | ||
| Use Part | Root | ||
| Habitat | SiChuan, YunNan, Shaanxi, GuiZhou, QingHai, NingXia | ||
| Flavor | Sweet, Pungent | ||
| Meridian Tropism | Liver, Heart, Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Apiales
-->Family: Apiaceae
-->Genus: Angelica
-->Species: Angelica sinensis
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| Pair Name | Levistolide A, Doxorubicin | |||
| Partner Name | Doxorubicin | |||
| Disease Info | [ICD-11: 2B33.2] | Chronic myeloid leukemia | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | ABCB1 | hsa5243 |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Expression | CASP3 | hsa836 | |
| In Vitro Model | K562/dox | Doxorubicin-resistant blast phase chronic myelogenous leukemia | Homo sapiens (Human) | N.A. |
| Result | Levistolide A synergistically enhances doxorubicin‑induced apoptosis of k562/dox cells by decreasing MDR1 expression through the ubiquitin pathway | |||
