| Name | Interleukin-4 | ||
| UniProt ID | IL4_HUMAN | ||
| Gene Name | IL4 | ||
| Gene ID | 3565 | ||
| Synonyms |
IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4
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| Sequence |
MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAAS
KNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGL NSCPVKEANQSTLENFLERLKTIMREKYSKCSS |
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| Pathway Map | MAP LINK | ||
| T.C. Number | 1.A.14.3.13; 8.A.43.1.16 | ||
| KEGG ID | hsa3565 | ||
| TTD ID | T00239 | ||
| Pfam | PF00727; PF11051 | ||
| Pair Name | Quercetin, Anti-PD-1 antibody | |||
| Phytochemical | Quercetin | |||
| Drug | Anti-PD-1 antibody | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Regulate Info | Down-regulation | Interleukin-4 | Expression | |
| Result | Quercetin/anti-PD-1 antibody combination therapy reshaped HCC tumor microenvironment in mice in parallel with regulating the GM and macrophage immunity. | |||
| Pair Name | Hesperetin, Capecitabine | |||
| Phytochemical | Hesperetin | |||
| Drug | Capecitabine | |||
| Disease Info | [ICD-11: 2B90.Z] | Colon cancer | Investigative | |
| Regulate Info | Up-regulation | Interleukin-4 | Expression | |
| Result | It can be suggested that both HES and CAP, singly or in combination, have the potential to exert chemopreventive effects against DMH-induced colon carcinogenesis via the suppression of oxidative stress, the stimulation of the antioxidant defense system, the attenuation of inflammatory effects, the reduction in cell proliferation and the enhancement of apoptosis. | |||
| Pair Name | Hesperetin, Capecitabine | |||
| Phytochemical | Hesperetin | |||
| Drug | Capecitabine | |||
| Disease Info | [ICD-11: 2B90.Z] | Colon cancer | Investigative | |
| Regulate Info | Up-regulation | Interleukin-4 | Expression | |
| Result | It can be suggested that both HES and CAP, singly or in combination, have the potential to exert chemopreventive effects against DMH-induced colon carcinogenesis via the suppression of oxidative stress, the stimulation of the antioxidant defense system, the attenuation of inflammatory effects, the reduction in cell proliferation and the enhancement of apoptosis. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Quercetin/Anti-PD-1 Antibody Combination Therapy Regulates the Gut Microbiota, Impacts Macrophage Immunity and Reshapes the Hepatocellular Carcinoma Tumor Microenvironment. Front Biosci (Landmark Ed). 2023 Dec 1;28(12):327. doi: 10.31083/j.fbl2812327. | Click |
| 2 | Hesperetin and Capecitabine Abate 1,2 Dimethylhydrazine-Induced Colon Carcinogenesis in Wistar Rats via Suppressing Oxidative Stress and Enhancing Antioxidant, Anti-Inflammatory and Apoptotic Actions. Life (Basel). 2023 Apr 11;13(4):984. doi: 10.3390/life13040984. | Click |
| 3 | Hesperetin and Capecitabine Abate 1,2 Dimethylhydrazine-Induced Colon Carcinogenesis in Wistar Rats via Suppressing Oxidative Stress and Enhancing Antioxidant, Anti-Inflammatory and Apoptotic Actions. Life (Basel). 2023 Apr 11;13(4):984. doi: 10.3390/life13040984. | Click |
