| Chineses Pinyin | YuMi | ||
| Use Part | Style and stigma | ||
| Habitat | China | ||
| Flavor | Kidney; Stomach; Liver; Gallbladder | ||
| Meridian Tropism | Sweet; Tasteless | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Poales
-->Family: Poaceae
-->Genus: Zea
-->Species: Zea mays
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| Pair Name | Hyaluronic acid, Doxorubicin | |||
| Partner Name | Doxorubicin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Immunomodulatory | |||
| Gene Regulation | Up-regulation | Cleavage | CASP3 | hsa836 |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| 4T1 | Malignant neoplasms of the mouse mammary gland | Mus musculus (Mouse) | CVCL_0125 | |
| In Vivo Model | Breast cancer xenograft mouse model was constructed by transplanting 4T1 cells subcutaneously to the nude mice and used in the following experiments at 10 d after inoculation | |||
| Result | This multifunctional nanoparticle system could deliver R848 and DOX respectively to tumor microenvironment and breast cancer cells to achieve synergistic effects of immunotherapy and chemotherapy against breast cancer. | |||
