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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Hesperetin, Doxorubicin
Phytochemical Name Hesperetin (PubChem CID: 72281 )
Anticancer drug Name Doxorubicin (PubChem CID: 31703 )
Structure of
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 87
Ref_1
Pair Name Hesperetin, Doxorubicin
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation Down-regulation Expression ERBB2 hsa2064
Down-regulation Expression MMP9 hsa4318
Down-regulation Expression RAC1 hsa5879
In Vitro Model MCF-7/HER2-18 Invasive breast carcinoma Homo sapiens (Human) CVCL_0U80
Result These results indicated that the combination of Hst and Dox-induced cell cycle arrest, apoptosis, decreased HER2, Rac1, MMP9 expression, and cell migration. Thus, Hst may have the potential to be developed as a co-chemotherapeutic agent combined with doxorubicin toward HER2 overexpressing breast cancer cells.
03. Reference
No. Title Href
1 Cytotoxic and Antimetastatic Activity of Hesperetin and Doxorubicin Combination Toward Her2 Expressing Breast Cancer Cells. Asian Pac J Cancer Prev. 2020 May 1;21(5):1259-1267. doi: 10.31557/APJCP.2020.21.5.1259. Click
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