glaucocalyxin B
| Name | Glaucocalyxin B | ||
| PubChem CID | 14193399 | ||
| Molecular Weight | 374.5g/mol | ||
| Synonyms |
glaucocalyxin B |
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| Formula | C₂₂H₃₀O₅ | ||
| SMILES | CC(=O)OC1C2CCC3C1(C(CC4C3(CCC(=O)C4(C)C)C)O)C(=O)C2=C | ||
| InChI | 1S/C22H30O5/c1-11-13-6-7-14-21(5)9-8-16(24)20(3,4)15(21)10-17(25)22(14,18(11)26)19(13)27-12(2)23/h13-15,17,19,25H,1,6-10H2,2-5H3/t13-,14-,15+,17+,19+,21-,22-/m0/s1 | ||
| InChIKey | LSUXOKVMORWDLT-KEXKRWMXSA-N | ||
| CAS Number | 80508-81-2 | ||
| ChEMBL ID | CHEMBL563681 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | LanEXiangChaCai | ||
| Use Part | Whole herb | ||
| Habitat | JiangSu, HeNan, SiChuan, GuiZhou, YunNan, XiZang, ChongQing, GanSu | ||
| Flavor | Pungent; Bitter | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Isodon
-->Species: Isodon japonicus
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| Pair Name | Glaucocalyxin B, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2C73] | Ovarian cancer | Investigative | |
| Biological Phenomena | Induced-->Oxidative Stress | |||
| Gene Regulation | Up-regulation | Phosphorylation | MAPK8 | hsa5599 |
| In Vitro Model | A2780 | Ovarian endometrioid adenocarcinoma | Homo sapiens (Human) | CVCL_0134 |
| A2780/CDDP | Ovarian endometrioid adenocarcinoma | Homo sapiens (Human) | CVCL_D619 | |
| Result | GLB enhances the sensitivity of ovarian cancer cells to cisplatin via increasing reactive oxygen species (ROS) levels, the phosphorylation of c-Jun N-terminal kinase (JNK), and DNA damage. A synergistic inhibitory effect of GLB with cisplatin was also observed in the cells which were resistance to cisplatin. These data suggest that GLB can sensitize ovarian cancer cells to cisplatin by increasing ROS levels. | |||
