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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Glabridin, Tamoxifen
Phytochemical Name Glabridin (PubChem CID: 124052 )
Anticancer drug Name Tamoxifen (PubChem CID: 2733526 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 430
Ref_1
Pair Name Glabridin, Tamoxifen
Disease Info [ICD-11: 2C76] Endometrial cancer Investigative
Gene Regulation Down-regulation Expression BCL2 hsa596
Up-regulation Expression ESR1 hsa2099
In Vitro Model MCF-7 Invasive breast carcinoma of no special type Homo sapiens (Human) CVCL_0031
Ishikawa Endometrial adenocarcinoma Homo sapiens (Human) CVCL_2529
Result These results suggested that the combination of tamoxifen and glabridin has potential to be used as an estrogen replacement drug with a reduced risk of endometrial cancer that has arisen from the intake of tamoxifen.
03. Reference
No. Title Href
1 The Combinatory Effects of Glabridin and Tamoxifen on Ishikawa and MCF-7 Cell Lines. Nat Prod Commun. 2015 Sep;10(9):1573-6. Click
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