| Pair Name | Gamma-Tocotrienol, Cisplatin | ||
| Phytochemical Name | Gamma-Tocotrienol (PubChem CID: 5282349 ) | ||
| Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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| Pair Name | Gamma-Tocotrienol, Cisplatin | |||
| Disease Info | [ICD-11: 2C51] | Mesothelioma | Investigative | |
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Down-regulation | Phosphorylation | BAD | hsa572 | |
| In Vitro Model | NCI-H28 | Pleural sarcomatoid mesothelioma | Homo sapiens (Human) | CVCL_1555 |
| Result | These results suggest that the combination therapy of cisplatin with TRF is a plausible strategy for achieving tolerance for the chemotherapeutic agent in MM therapy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | The tocotrienol-rich fraction from rice bran enhances cisplatin-induced cytotoxicity in human mesothelioma H28 cells. Phytother Res. 2010 Sep;24(9):1317-21. doi: 10.1002/ptr.3107. | Click |
