Pair Name	Gambogic Acid, Sunitinib
Disease Info	[ICD-11: 2C90.0]	Renal cell carcinoma		Investigative
Biological Phenomena	Inhibition-->Angiogenesis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CDKN1A	hsa1026
	Down-regulation	Expression	VEGFA	hsa7422
In Vitro Model	786-O	Renal cell carcinoma	Homo sapiens (Human)	CVCL_1051
	Caki-1	Clear cell renal cell carcinoma	Homo sapiens (Human)	CVCL_0234
In Vivo Model	Caki-1 cells (2×10⁶) in 100 ul RPMI-1640 and 100 ul of matrigel were used to inject subcutaneously into each mouse (5-week-old male athymic BALB/c nu/nu mice).
Result	Our results show that the joint use of GA and SU can provide greater antitumor efficacy compared to either drug alone and thus may offer a new treatment strategy for renal cell carcinoma.