| Pair Name | Emodin, Gemcitabine | ||
| Phytochemical Name | Emodin (PubChem CID: 3220 ) | ||
| Anticancer drug Name | Gemcitabine (PubChem CID: 60750 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Emodin, Gemcitabine | |||
| Disease Info | [ICD-11: 2C10.Z] | Pancreatic cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | CDH13 | hsa1012 |
| Down-regulation | Expression | XIAP | hsa331 | |
| Down-regulation | Expression | NFKB1 | hsa4790 | |
| In Vitro Model | SW1990 | Pancreatic adenocarcinoma | Homo sapiens (Human) | CVCL_1723 |
| Result | This study suggests that emodin enhances the antitumor effect of gemcitabine in SW1990 pancreatic cancer in vitro and in vivo, which may be via the downregulation of NF-κB expression, thus inhibiting the expression of XIAP. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Enhanced antitumor efficacy by the combination of emodin and gemcitabine against human pancreatic cancer cells via downregulation of the expression of XIAP in vitro and in vivo. Int J Oncol. 2011 Nov;39(5):1123-31. doi: 10.3892/ijo.2011.1115. | Click |
