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7,8-dihydroxy-2H-1-benzopyran-2-one, 7,8-dihydroxycoumarin, daphnetin

No.	Title	Href
1	Daphnetin protects against cisplatin-induced nephrotoxicity by inhibiting inflammatory and oxidative response. Int Immunopharmacol. 2018 Dec;65:402-407. doi: 10.1016/j.intimp.2018.10.018.	`Click`
2	Daphnetin, a Coumarin with Anticancer Potential against Human Melanoma: In Vitro Study of Its Effective Combination with Selected Cytostatic Drugs. Cells. 2023 Jun 9;12(12):1593. doi: 10.3390/cells12121593.	`Click`

No.

Title

Href

Daphnetin protects against cisplatin-induced nephrotoxicity by inhibiting inflammatory and oxidative response. Int Immunopharmacol. 2018 Dec;65:402-407. doi: 10.1016/j.intimp.2018.10.018.

Click

Daphnetin, a Coumarin with Anticancer Potential against Human Melanoma: In Vitro Study of Its Effective Combination with Selected Cytostatic Drugs. Cells. 2023 Jun 9;12(12):1593. doi: 10.3390/cells12121593.

Click

Name	Daphnetin
PubChem CID	5280569
Molecular Weight	178.14g/mol
Synonyms	7,8-dihydroxy-2H-1-benzopyran-2-one, 7,8-dihydroxycoumarin, daphnetin
Formula	C₉H₆O₄
SMILES	C1=CC(=C(C2=C1C=CC(=O)O2)O)O
InChI	1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H
InChIKey	ATEFPOUAMCWAQS-UHFFFAOYSA-N
CAS Number	486-35-1
ChEMBL ID	CHEMBL244948
ChEBI ID	CHEBI:17313
Herb ID	HBIN022677
KEGG ID	C03093
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	LangDu
Use Part	Root
Habitat	Russia, SiChuan, GuiZhou, YunNan, XiZang, ChongQing
Flavor	Pungent
Meridian Tropism	Liver, Spleen
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Malpighiales 　　　　-->Family: Euphorbiaceae 　　　　　-->Genus: Euphorbia 　　　　　　-->Species: Euphorbia ebracteolata

Chineses Pinyin	QianJinZi
Use Part	Ripe Seed Without Seed Coat
Habitat	JiLin, LiaoNing, NeiMengGu, HeBei, Shaanxi, GanSu, XinJiang, ShanDong, JiangSu, AnHui, ZheJiang, JiangXi, FuJian, HeNan, HuBei, HuNan, GuangXi, SiChuan, GuiZhou, YunNan, XiZang
Flavor	Pungent
Meridian Tropism	Liver, Kidney, Large intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Malpighiales 　　　　-->Family: Euphorbiaceae 　　　　　-->Genus: Euphorbia 　　　　　　-->Species: Euphorbia lathyris

Chineses Pinyin	QianJinZiShuang
Use Part	Processed Products Of Semen Euphorbiae
Habitat	JiLin, LiaoNing, NeiMengGu, HeBei, Shaanxi, GanSu, XinJiang, ShanDong, JiangSu, AnHui, ZheJiang, JiangXi, FuJian, HeNan, HuBei, HuNan, GuangXi, SiChuan, GuiZhou, YunNan, XiZang
Flavor	Pungent
Meridian Tropism	Liver, Kidney, Large intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Malpighiales 　　　　-->Family: Euphorbiaceae 　　　　　-->Genus: Euphorbia 　　　　　　-->Species: Euphorbia lathyris

Chineses Pinyin	HuiHuiDou
Use Part	Seed
Habitat	GanSu, QingHai, Shaanxi, ShanXi, HeBei
Flavor	Sweet
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Cicer 　　　　　　-->Species: Cicer arietinum

Chineses Pinyin	RuiXiangGen
Use Part	Root
Habitat	China
Flavor	Pungent, Sweet
Meridian Tropism	Spleen, Liver, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Malvales 　　　　-->Family: Thymelaeaceae 　　　　　-->Genus: Daphne 　　　　　　-->Species: Daphne odora

Chineses Pinyin	XuSuiZiJingZhongBaiZhi
Use Part	White Juice In Stem
Habitat	HeiLongJiang, JiLin, LiaoNing, HeBei, ShanXi, JiangSu, ZheJiang, FuJian, TaiWan, HeNan, HuNan, GuangXi, SiChuan, GuiZhou, YunNan
Flavor	Pungent
Meridian Tropism	Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Malpighiales 　　　　-->Family: Euphorbiaceae 　　　　　-->Genus: Euphorbia 　　　　　　-->Species: Euphorbia pekinensis

Chineses Pinyin	RuiXiang
Use Part	Root
Habitat	China
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Malvales 　　　　-->Family: Thymelaeaceae 　　　　　-->Genus: Daphne 　　　　　　-->Species: Daphne odora

Pair Name	Daphnetin, Mitoxantrone
Partner Name	Mitoxantrone
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Biological Phenomena	Inhibition-->Cell metastasis
In Vitro Model	FM55M2	Cutaneous melanoma	Homo sapiens (Human)	CVCL_C590
	SK-MEL-28	Cutaneous melanoma	Homo sapiens (Human)	CVCL_0526
	FM55p	Cutaneous melanoma	Homo sapiens (Human)	CVCL_C591
	A-375	Amelanotic melanoma	Homo sapiens (Human)	CVCL_0132
Result	Daphnetin, a Coumarin with Anticancer Potential against Human Melanoma: In Vitro Study of Its Effective Combination with Selected Cytostatic Drugs

Pair Name	Daphnetin, Cisplatin
Partner Name	Cisplatin
Disease Info	Nephrotoxicity			/
Gene Regulation	Up-regulation	Expression	GABPA	hsa2551
Gene Regulation	Up-regulation	Expression	HMOX1	hsa3162
Result	The results of this study suggested that daphnetin inhibited cisplatin-induced nephrotoxicity by inhibiting NF-κB and activating Nrf2 signaling pathways. Daphnetin might be a promising agent in the treatment of kidney injury.